Cartilage- and subchondral bone derived factors regulate collagen production in MSC

Distribution of subchondral bone density and cartilage

Subchondral bone density (by means of CT osteoabsorptiometry), and cartilage thickness (directly measured on photocopies of frozen sections), were examined in 30 human patellae, with an age range from 47 to 90 y. A surface demonstration of the distribution was prepared, and representative pictures produced by summation with a computer. Subchondral bone-density maxima were found in the proximal ...

Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes

INTRODUCTION Osteoarthritis (OA) is characterized by an imbalance in cartilage and underlying subchondral bone homeostasis. We hypothesized that signals from the subchondral bone may modulate production of matrix components, alter chondrogenic differentiation potential of cocultured bone marrow-derived mesenchymal stem cells (BMSC) and induce a phenotypic shift in differentiated OA chondrocytes...

Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism.

Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface

The cartilage lesion resulting from osteoarthritis (OA) always extends into subchondral bone. It is of great importance for simultaneous regeneration of two tissues of cartilage and subchondral bone. 3D-printed Sr5(PO4)2SiO4 (SPS) bioactive ceramic scaffolds may achieve the aim of regenerating both of cartilage and subchondral bone. We hypothesized that strontium (Sr) and silicon (Si) ions rele...

Quantitative Ultrasound Imaging Detects Articular Cartilage and Subchondral Bone Changes in Spontaneous Cartilage Degeneration

+*Saarakkala, S; **Laasanen, M S; ***Töyräs, J; **Jurvelin, J S +*Departments of Nuclear Medicine and Radiology, Mikkeli Central Hospital, Porrassalmenkatu 35-37, FIN-50100 Mikkeli, Finland [email protected]